Scientific Papers - March 2022

For March, the WFADHD is pleased to highlight three papers.

The first of these papers is a systematic review and meta-analysis about neurodevelopmental disorders in children of patients with autoimmune or inflammatory disorders. The authors found that these disorders are associated with autism spectrum disorder and ADHD in the offspring.

The second paper from Müller et al. analyses global DNA methylation changes in adults with ADHD and its comorbidity with bipolar disorders. The study demonstrated an association between global DNA methylation, ADHD, and its comorbidity with bipolar disorders, and associations between polygenic risk scores for specific psychiatric disorders and global DNA methylation. The findings add to previous evidence that epigenetic mechanisms may be a relevant piece in the psychiatric disorders' etiological landscape.

The third paper is a cross-disorder analysis of shared genetic components between cortical structures and major psychiatric disorders from Li et al. by using a genome-wide association study. The results showed medium-to-strong correlations of genetic components in ADHD, bipolar disorder, major depressive disorder, and schizophrenia while autism spectrum disorder was correlated with ADHD, bipolar disorder, and schizophrenia.